This villa, deriving the name from a chapel that existed in its proximity in the 18th century, was the first one to be explored in the course of excavations carried out between 1749 and 1754. The villa was re-buried after the removal of its furnishings and of the better preserved frescoes. Excavations were resumed on 1950. Villa San Marco is one of the largest villas ever discovered in Campania, measuring more than 11000 square meters.